Gastroesophageal Reflux Disease (GERD)

Condition Summary

Almost everyone has occasionally experienced heartburn, but about 25 million American adults suffer daily from severe, chronic heartburn. It is that burning sensation felt behind the breastbone and sometimes in the neck and throat. Heartburn is caused by stomach acid refluxing or splashing up into the esophagus - the muscular tube that connects the throat to the stomach. Occasional heartburn is nothing to be concerned about. However, anyone who has heartburn on a regular basis should consult a physician. Constant exposure to stomach acid can irritate the lining of the esophagus and cause other medical problems. Serious heartburn is known as gastroesophageal reflux disease or GERD.

What Is GERD?
The esophagus carries food and liquid into the stomach. At the lower end of the esophagus where it enters the stomach, there is a strong muscular ring called the lower esophageal sphincter (LES). The LES should remain tightly closed, except to allow food and liquid to pass into the stomach. Reflux occurs when the LES is not working and closing properly. The LES may relax for periods of time throughout the day and night, or it may be constantly too weak to function effectively. This allows the stomach's acid juices to flow into the esophagus. How severe the disease becomes depends on how weakened the LES is, and the amount and duration of acid refluxed into the esophagus.

It is also common to find a hiatal hernia complicating GERD. With a hiatal hernia, the upper part of the stomach actually pushes up into the chest through a weakness in the diaphragm. The diaphragm is the thin, flat muscle that separates the lungs from the abdomen. When part of the upper stomach is stuck above the diaphragm, stomach acid is retained there for a longer period and is more likely to reflux into the esophagus.

What Causes GERD and Its Symptoms?
Frequent heartburn is the most common symptom, however patients may also experience some of the following:

Certain diet and lifestyle choices can contribute to the condition. For example, certain foods increase acid production, and a high concentration of fatty foods increase the time food remains in the stomach. Chocolate, peppermint, coffee, alcoholic beverages, and especially nicotine in cigarette smoke weaken or relax the LES. Obesity places added pressure on the upper abdomen, and during pregnancy the LES weakens for unknown reasons.

Complications
Complications occur when GERD is severe or long-standing. Constant irritation of the esophagus by stomach acid can lead to inflammation, ulcers, and bleeding. Anemia or low blood count may develop. Over time, scarring and narrowing of the esophagus can also develop, making it difficult to swallow foods and liquids. This narrowing is called a stricture. Some patients develop a condition called Barrett's esophagus, which is a serious change in the cells lining the esophagus. Barrett's esophagus may be a forerunner of esophageal cancer.

Diagnosis
The diagnosis can usually be suspected by the physician, simply by taking the medical history. Beyond that, the physician may order an x-ray examination of the esophagus and stomach. For this x-ray, the patient swallows a liquid containing barium. This makes it possible to see the reflux and a hiatal hernia on the x-ray.

Endoscopy is the most important test for patients with GERD. Performed with the patient under mild sedation, endoscopy allows the physician to examine the lining of the esophagus and stomach with a thin, lighted, flexible tube called an endoscope. This exam is helpful in determining how severe the disease is, how much tissue damage there is, and if there are any complications. Certain conditions, such as narrowing or stricture in the esophagus, can usually be corrected during the endoscopic procedure. During an endoscopy, the physician can also look for signs of Barrett's esophagus, and perform a biopsy to see if precancerous changes have occurred.

There are also other tests that are helpful. A pressure recording of the esophagus is called esophageal manometry. It measures the pressure in the LES and any abnormal muscle contractions in the main part of the esophagus. Finally, a 12 to 24 hour recording of the acidity in the esophagus (an esophageal pH test) is often helpful.

Treatment
Treatment is aimed at reducing reflux and damage to the lining of the esophagus. Initial treatment may be recommended lifestyle changes. Patients with GERD should follow these recommendations:

Lifestyle changes are often all that is needed to correct mild forms of GERD. When symptoms are moderate to severe, the physician may prescribe medications. Some that reduce stomach acid include Tagamet, Zantac, Pepcid, and Axid. Certain potent newer drugs, such as Prilosec and Prevacid, can almost eliminate stomach acid entirely. These two drugs are most frequently used when GERD is severe. Other medications, such as Propulsid and Reglan (generic: metoclopramide) tighten the LES. These may be especially useful at night when reflux often occurs.

A number of patients with GERD may need surgery to strengthen the LES. This procedure is called fundoplication. Previously this surgery required a major operation, often through the chest. It is a difficult operation for the patient, with a long recovery. Fundoplication surgery is now usually done by laparoscopy, which is minimally invasive surgery performed with a tiny incision at the naval. The patient usually returns home 1 to 2 days after surgery, with few problems. There is a newer treatment called endoluminal gastroplication which is an outpatient procedure combining the use of endoscopes with a special suturing device to make plications or pleats in the wall of the esophagus just below the LES. Esophageal endoscopy and endoluminal gastroplication are done under sedation, with no incisions whatsoever. As an outpatient procedure, the patient returns home the same day and usually returns to normal daily activity the next day.

Surgery should not be considered until all other measures have been tried. Surgery is often seriously considered for an otherwise healthy individual when the disease is severe, or the patient does not want to face the expense or regimen of long-term treatment with medications.

Summary
GERD is a common problem that requires medical attention when symptoms and tissue damage become troublesome. Fortunately, there is a great deal that can now be done about GERD. Lifestyle changes can help, and there are many medications to treat and correct GERD. Surgical techniques ranging from outpatient endoluminal gastroplication, to minimally-invasive laparoscopy have greatly improved treatment and in many cases eliminated the need for open chest surgery to correct the problem.