Peptic Ulcer Disease (PUD)

Condition Summary

Peptic ulcer disease (PUD) is a very common ailment, affecting one out of eight persons in the United States. The causes of PUD have gradually become clear and with this understanding have come new and better ways to treat ulcers and even cure them.

What Causes Peptic Ulcers?
An ulcer is an open sore in the lining of the stomach or intestine, much like mouth or skin ulcers. Peptic ulcers are eventually caused by acid and pepsin, a digestive stomach enzyme. These ulcers can occur in the stomach, where they are called gastric ulcers. Or they can occur in the first portion of the intestine beyond the stomach, in which case they are called duodenal ulcers.

It is almost always the acid that causes the injury to the bowel wall. However, a revolutionary and starling recent discovery is that most peptic ulcers result from a stomach infection caused by the bacteria, Helicobacter pylori.

So, helicobacter pylori and these drugs are the two major factors that bring on ulcers. There also is a small group of patients that produce very large amounts of acid uncontrollably, thereby causing ulcers. Finally, some people get ulcers for unknown reasons.

Ulcers cause gnawing, burning pain in the upper abdomen. These symptoms frequently occur several hours following a meal, after the food leaves the stomach but while acid production is still high. The burning sensation can occur during the night and be so extreme as to wake the patient. Instead of pain, some patients experience intense hunger or bloating. Antacids and milk usually give temporary relief. Other patients have no pain but have black stools, indicating that the ulcer is bleeding. Bleeding is a serious complication of ulcers.

A diagnosis of peptic ulcers can be suspected from the patient's medical history. However, the diagnosis should always be confirmed either by an upper intestinal endoscopy which allows direct examination of the ulcer, or by a barium x-ray of the stomach. With endoscopy, a biopsy is usually obtained of a gastric ulcer to determine if it is malignant and requires surgery.

Therapy of PUD has undergone profound changes. The first has been the development of drugs which suppress stomach acid (Pepcid, Tagamet, Zantac, Axid) or even stop it altogether (Prilosec). These acid-suppressing drugs have been dramatically effective in relieving symptoms and allowing ulcers to heal. If an ulcer has been caused by aspirin or an arthritis drug, then no subsequent treatment is usually needed. Avoiding these drugs should prevent ulcer recurrence.

The second major change in PUD treatment has been the discovery of the Helicobacter pylori infection. When this infection is cleared by antibiotics, the infection and the ulcer do not come back. So, increasingly, physicians are not just suppressing the ulcer with the acid-reducing drugs but they are able to cure the underlying ulcer problem by getting rid of the bacterial infection. If not, ulcers invariably recur.

There are a number of antibiotic programs available now to treat helicobacter pylori. For example, Pepto-Bismol is an active antibiotic against the bacteria but must be used in conjunction with other drugs. The physician will select the most appropriate treatment program for the individual patient.

Other factors are still very important in treating, controlling, and curing peptic ulcers:

The new era of peptic ulcer disease is at hand. With a firm understanding of how ulcers occur, with the potent acid-suppressing drugs now available, and with the knowledge that peptic ulcers caused by helicobacter pylori can now be cured, the future in indeed bright for patients with ulcers.